Overview Zika virus is a mosquito-borne virus first identified in Uganda in 1947 in a Rhesus macaque monkey followed by evidence of infection and disease in humans in other African countries in the 1950s. From the 1960s to 1980s, sporadic human infections were detected across Africa and Asia. Zika virus is a flavivirus that was first isolated in 1947 from a febrile rhesus macaque monkey in the Zika Forest of Uganda and later identified in Aedes africanus mosquitoes from the same forest ().In 1954, the first 3 cases of human infection were reported in Nigeria ().Serosurveillance studies in humans suggest that Zika virus is widespread throughout Africa, Asia, and Oceania (Technical In 2022, a total of 3 123 752 cases (suspected and confirmed) of arboviral disease were reported in the Region of the Americas. Of these, 2 809 818 (90%) were dengue cases and 273 685 (9%) were chikungunya cases. This represents a proportional increase of approximately 119% compared to 2021. In 2022, both dengue and chikungunya peaked at For information related to Zika, please see Zika Travel Information. For all current travel notices, please visit the travel notices page. Page last reviewed: June 30, 2021. Content source: National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) Division of Global Migration Health (DGMH) 1 These countries have a potential risk of Zika, but we do not have accurate information on the current level of risk. As a result, detection and reporting of new outbreaks may be delayed. 2 Because Aedes aegypti mosquitoes (the mosquitoes that most commonly spreads Zika) are present in these countries, Zika has the potential to be present, along with other mosquito-borne infections. The Zika virus disease is usually mild and requires no specific treatment. The most common symptoms are mild fever, skin rash, headache, muscle and joint pain and inflammation of the underside of the eyelid. These symptoms normally last for 2-7 days. If symptoms worsen, they should seek medical care and advice. .

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